Publications
N Hewitt, N., Ma, N., Arang, N., Martin, S. A., Prakash, A., DiBerto, J. F., Knight, K. M., Ghosh, S., Olsen, R., Roth, B. L., Gutkind, J. S., Vaidehi, N., Campbell, S. L., Dohlman, H. G. (2023) Catalytic site mutations confer multiple states of G protein activation. Sci. Signal. 16, eabq7842.
Huynh, M. V., Hobbs, G. A., Schaefer, A., Pierobon, M., Carey, L. M., Diehl, J. N., DeLiberty, J. M., Thurman, R. D., Cooke, A. R., Goodwin, C. M., Cook, J. H., Lin, L., Waters, A. M., Rashid, N. U., Petricoin III, E. F., Campbell, S. L., Haigis, K. M., Simeone, D. M., Lyssiotis, C. A., Cox, A. D., Der, C. J. (2022) Functional and biological heterogeneity of KRASQ61 mutations. Sci. Signal. 15, eabn2694.
Huynh, M. V., Parsonage, D., Forshaw, T. E., Chirasani, V. R., Hobbs, G. A., Wu, H., Lee, J., Furdui, C. M., Poole, L. B., and Campbell, S. L. (2022) Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition. J. Biol. Chem. 298, 102186.
Murphy, B. M., Terrell, E. M., Chirasani, V. R., Weiss, T. J., Lew, R. E., Holderbaum, A. M., Dhakal, A., Posada, V., Fort, M., Bodnar, M. S., Carey, L. M., Chen, M., Burd, C. J., Coppola, V., Morrison, D. K., Campbell, S. L., and Burd, C. E. (2022) Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation. Nat Commun 13, 3153.
Campbell, S.L. and Philips, M. R. (2021) Post-translational modification of RAS proteins. Current Opinion in Structural Biology 71, 180-192.
Osaka, N., Hirota, Y., Ito, D., Ikeda, Y., Kamata, R., Fujii, Y., Chirasani, V. R., Campbell, S. L., Takeuchi, K., Senda, T., and Sasaki, A. T. (2021) Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification. Front. Mol. Biosci. 8, 642.
Nair, V. V., Yin, G., Zhang, J., Hancock, J. F., Campbell, S. L., and Gorfe, A. A. (2021) Monoubiquitination of KRAS at Lysine104 and Lysine147 Modulates Its Dynamics and Interaction with Partner Proteins. J. Phys. Chem. B. 125, 4681–4691.
Knight, K. M., Ghosh, S., Campbell, S. L., Lefevre, T. J., Olsen, R. H. J., Smrcka, A. V, Valentin, N. H., Yin, G., Vaidehi, N., and Dohlman, H. G. (2021) A universal allosteric mechanism for G protein activation. Mol. Cell. 81, 1384-1396.e6.
Martinez, N. G., Thieker, D. F., Carey, L. M., Rasquinha, J. A., Kistler, S. K., Kuhlman, B. A., and Campbell, S. L. (2021) Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ.
J. Mol. Biol. 433, 166838.
Yin, G., Zhang, J., Nair, V., Truong, V., Chaia, A., Petela, J., Harrison, J., Gorfe, A. A., and Campbell, S. L. (2020) KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface. iScience. 23, 101448.
Arrington, M. E., Temple, B., Schaefer, A., and Campbell, S. L. (2020) The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2. J. Biol. Chem. 295, 12130–12142.
Sarker, M., Goliaei, A., Golesi, F., Poggi, M., Cook, A. A., Khan, M. A. I., Temple, B. R., Stefanini, L., Canault, M., Bergmeier, W., and Campbell, S. L. (2020) Subcellular localization of Rap1 GTPase activator CalDAG‐GEFI is orchestrated by interaction of its atypical C1 domain with membrane phosphoinositides. J. Thromb. Haemost. 18, 693–705.
Hobbs, G. A., Baker, N. M., Miermont, A. M., Thurman, R. D., Pierobon, M., Tran, T. H., Anderson, A. O., Waters, A. M., Diehl, J. N., Papke, B., Hodge, R. G., Klomp, J. E., Goodwin, C. M., DeLiberty, J. M., Wang, J., Ng, R. W. S., Gautam, P., Bryant, K. L., Esposito, D., Campbell, S. L., Petricoin, E. F., Simanshu, D. K., Aguirre, A. J., Wolpin, B. M., Wennerberg, K., Rudloff, U., Cox, A. D., and Der, C. J. (2020) Atypical KRASG12R mutant is impaired in PI3K signaling and macropinocytosis in pancreatic cancer. Cancer Discov. 10, 104–123.
Dohlman, H. G., and Campbell, S. L. (2019) Regulation of large and small G proteins by ubiquitination. J. Biol. Chem. 294, 18613–18623.
Lee, H. T., Sharek, L., O’Brien, E. T., Urbina, F. L., Gupton, S. L., Superfine, R., Burridge, K., and Campbell, S. L. (2019) Vinculin and metavinculin exhibit distinct effects on focal adhesion properties, cell migration, and mechanotransduction. PLoS One. 14, e0221962.
Hsu, A. P., Donkó, A., Arrington, M. E., Swamydas, M., Fink, D., Das, A., Escobedo, O., Bonagura, V., Szabolcs, P., Steinberg, H. N., Bergerson, J., Skoskiewicz, A., Makhija, M., Davis, J., Foruraghi, L., Palmer, C., Fuleihan, R. L., Church, J. A., Bhandoola, A., Lionakis, M. S., Campbell, S., Leto, T. L., Kuhns, D. B., and Holland, S. M. (2019) Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects. Blood. 133, 1977–1988.
Sarker, M., Lee, H. T., Mei, L., Krokhotin, A., de los Reyes, S. E., Yen, L., Costantini, L. M., Griffith, J., Dokholyan, N. V., Alushin, G. M., and Campbell, S. L. (2019) Cardiomyopathy Mutations in Metavinculin Disrupt Regulation of Vinculin-Induced F-Actin Assemblies. J. Mol. Biol. 431, 1604–1618.
Krokhotin, A., Sarker, M., Sevilla, E. A., Costantini, L. M., Griffith, J. D., Campbell, S. L., and Dokholyan, N. V. (2019) Distinct Binding Modes of Vinculin Isoforms Underlie Their Functional Differences. Structure. 27, 1527-1536.e3.
Yoshino, H., Yin, G., Kawaguchi, R., Popov, K. I., Temple, B., Sasaki, M., Kofuji, S., Wolfe, K., Kofuji, K., Okumura, K., Randhawa, J., Malhotra, A., Majd, N., Ikeda, Y., Shimada, H., Kahoud, E. R., Haviv, S., Iwase, S., Asara, J. M., Campbell, S. L., and Sasaki, A. T. (2019) Identification of lysine methylation in the core GTPase domain by GoMADScan. PLoS One. 14, e0224443.
Zhu, C., Dukhovlinova, E., Council, O., Ping, L., Faison, E. M., Prabhu, S. S., Potter, E. L., Upton, S. L., Yin, G., Fay, J. M., Kincer, L. P., Spielvogel, E., Campbell, S. L., Benhabbour, S. R., Ke, H., Swanstrom, R., and Dokholyan, N. V. (2019) Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies. Nat. Commun. 10, 948.
Yin, G., Kistler, S., George, S. D., Kuhlmann, N., Garvey, L., Huynh, M., Bagni, R. K., Lammers, M., Der, C. J., and Campbell, S. L. (2017) A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation. J. Biol. Chem. 292, 4446–4456.
Thompson, P. M., Ramachandran, S., Case, L. B., Tolbert, C. E., Tandon, A., Pershad, M., Dokholyan, N. V., Waterman, C. M., and Campbell, S. L. (2017) A Structural Model for Vinculin Insertion into PIP2-Containing Membranes and the Effect of Insertion on Vinculin Activation and Localization. Structure. 25, 264–275.
Shellhammer, J. P., Morin-Kensicki, E., Matson, J. P., Yin, G., Isom, D. G., Campbell, S. L., Mohney, R. P., and Dohlman, H. G. (2017) Amino acid metabolites that regulate G protein signaling during osmotic stress. PLOS Genet. 13, e1006829.
Thurman, R., Siraliev-Perez, E., and Campbell, S. L. (2017) RAS ubiquitylation modulates effector interactions. Small GTPases. 11, 1–6.
V. Huynh, M., and L. Campbell, S. (2016) Getting a Handle on RAS-targeted Therapies: Cysteine Directed Inhibitors. Mini-Reviews Med. Chem. 16, 383–390.
Kim, L. Y., Thompson, P. M., Lee, H. T., Pershad, M., Campbell, S. L., and Alushin, G. M. (2016) The Structural Basis of Actin Organization by Vinculin and Metavinculin. J. Mol. Biol. 428, 10–25.
Case, L. B., Baird, M. A., Shtengel, G., Campbell, S. L., Hess, H. F., Davidson, M. W., and Waterman, C. M. (2015) Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions. Nat. Cell Biol. 17, 880–892.
Thompson, P. M., Beck, M. R., and Campbell, S. L. (2015) Protein-Protein Interaction Analysis by Nuclear Magnetic Resonance Spectroscopy (Meyerkord, C. L., and Fu, H. eds), pp. 267–279, Springer New York, New York, NY, 10.1007/978-1-4939-2425-7_16.
Wall, S. B., Oh, J.-Y., Mitchell, L., Laube, A. H., Campbell, S. L., Renfrow, M. B., and Landar, A. (2015) Rac1 modification by an electrophilic 15-deoxy Δ12,14-prostaglandin J2 analog. Redox Biol. 4, 346–354.
Hobbs, G. A., Mitchell, L. E., Arrington, M. E., Gunawardena, H. P., DeCristo, M. J., Loeser, R. F., Chen, X., Cox, A. D., and Campbell, S. L. (2015) Redox regulation of Rac1 by thiol oxidation. Free Radic. Biol. Med. 79, 237–250.
Hobbs, G. A., Gunawardena, H. P., and Campbell, S. L. (2014) Biophysical and Proteomic Characterization Strategies for Cysteine Modifications in Ras GTPases. in Methods in Molecular Biology, pp. 75–96, 1120, 75–96.
Brady, D. C., Crowe, M. S., Turski, M. L., Hobbs, G. A., Yao, X., Chaikuad, A., Knapp, S., Xiao, K., Campbell, S. L., Thiele, D. J., and Counter, C. M. (2014) Copper is required for oncogenic BRAF signalling and tumorigenesis. Nature. 509, 492–496.
Tolbert, C. E., Thompson, P. M., Superfine, R., Burridge, K., and Campbell, S. L. (2014) Correction to Phosphorylation at Y1065 in Vinculin Mediates Actin Bundling, Cell Spreading, and Mechanical Responses to Force. Biochemistry. 53, 6286–6286.
Thompson, P. M., Tolbert, C. E., Shen, K., Kota, P., Palmer, S. M., Plevock, K. M., Orlova, A., Galkin, V. E., Burridge, K., Egelman, E. H., Dokholyan, N. V., Superfine, R., and Campbell, S. L. (2014) Identification of an Actin Binding Surface on Vinculin that Mediates Mechanical Cell and Focal Adhesion Properties. Structure. 22, 697–706.
Burd, C. E., Liu, W., Huynh, M. V., Waqas, M. A., Gillahan, J. E., Clark, K. S., Fu, K., Martin, B. L., Jeck, W. R., Souroullas, G. P., Darr, D. B., Zedek, D. C., Miley, M. J., Baguley, B. C., Campbell, S. L., and Sharpless, N. E. (2014) Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. Cancer Discov. 10.1158/2159-8290.CD-14-0729.
Hobbs, G. A., Zhou, B., Cox, A. D., and Campbell, S. L. (2014) Rho GTPases, oxidation, and cell redox control. Small GTPases. 5, e28579.
Baker, R., Wilkerson, E. M., Sumita, K., Isom, D. G., Sasaki, A. T., Dohlman, H. G., and Campbell, S. L. (2013) Differences in the Regulation of K-Ras and H-Ras Isoforms by Monoubiquitination. J. Biol. Chem. 288, 36856–36862.
Hobbs, G. A., Bonini, M. G., Gunawardena, H. P., Chen, X., and Campbell, S. L. (2013) Glutathiolated Ras: Characterization and implications for Ras activation. Free Radic. Biol. Med. 57, 221–229.
Mitchell, L., Hobbs, G. A., Aghajanian, A., and Campbell, S. L. (2013) Redox Regulation of Ras and Rho GTPases: Mechanism and Function. Antioxid. Redox Signal. 18, 250–258.
Hobbs, G. A., Gunawardena, H. P., Baker, R., Chen, X., and Campbell, S. L. (2013) Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. Small GTPases. 4, 186–192.
Baker, R., Lewis, S. M., Sasaki, A. T., Wilkerson, E. M., Locasale, J. W., Cantley, L. C., Kuhlman, B., Dohlman, H. G., and Campbell, S. L. (2013) Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. Nat. Struct. Mol. Biol. 20, 46–52.
Beck, M. R., Dixon, R. D. S., Goicoechea, S. M., Murphy, G. S., Brungardt, J. G., Beam, M. T., Srinath, P., Patel, J., Mohiuddin, J., Otey, C. A., and Campbell, S. L. (2013) Structure and Function of Palladin’s Actin Binding Domain. J. Mol. Biol. 425, 3325–3337.
Thompson, P. M., Tolbert, C. E., and Campbell, S. L. (2013) Vinculin and metavinculin: Oligomerization and interactions with F-actin. FEBS Lett. 587, 1220–1229.
Tolbert, C. E., Burridge, K., and Campbell, S. L. (2013) Vinculin regulation of F-actin bundle formation. Cell Adh. Migr. 7, 219–225.
Thievessen, I., Thompson, P. M., Berlemont, S., Plevock, K. M., Plotnikov, S. V., Zemljic-Harpf, A., Ross, R. S., Davidson, M. W., Danuser, G., Campbell, S. L., and Waterman, C. M. (2013) Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J. Cell Biol. 202, 163–177.
Davis, M. F., Zhou, L., Ehrenshaft, M., Ranguelova, K., Gunawardena, H. P., Chen, X., Bonini, M. G., Mason, R. P., and Campbell, S. L. (2012) Detection of Ras GTPase protein radicals through immuno-spin trapping. Free Radic. Biol. Med. 53, 1339–1345.
Cable, J., Prutzman, K., Gunawardena, H. P., Schaller, M. D., Chen, X., and Campbell, S. L. (2012) In Vitro Phosphorylation of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase by Src Kinase. Biochemistry. 51, 2213–2223.
Vigil, D., Kim, T. Y., Plachco, A., Garton, A. J., Castaldo, L., Pachter, J. A., Dong, H., Chen, X., Tokar, B., Campbell, S. L., and Der, C. J. (2012) ROCK1 and ROCK2 Are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion. Cancer Res. 72, 5338–5347.
Bhattacharyya, D., Ramachandran, S., Sharma, S., Pathmasiri, W., King, C. L., Baskerville-Abraham, I., Boysen, G., Swenberg, J. A., Campbell, S. L., Dokholyan, N. V., and Chaney, S. G. (2011) Flanking Bases Influence the Nature of DNA Distortion by Platinum 1,2-Intrastrand (GG) Cross-Links. PLoS One. 6, e23582.
Davis, M. F., Vigil, D., and Campbell, S. L. (2011) Regulation of Ras proteins by reactive nitrogen species. Free Radic. Biol. Med. 51, 565–575.
Beck, M. R., Otey, C. A., and Campbell, S. L. (2011) Structural Characterization of the Interactions between Palladin and α-Actinin. J. Mol. Biol. 413, 712–725.
Shen, K., Tolbert, C. E., Guilluy, C., Swaminathan, V. S., Berginski, M. E., Burridge, K., Superfine, R., and Campbell, S. L. (2011) The Vinculin C-terminal Hairpin Mediates F-actin Bundle Formation, Focal Adhesion, and Cell Mechanical Properties*. J. Biol. Chem. 286, 45103–45115.
Vigil, D., Martin, T. D., Williams, F., Yeh, J. J., Campbell, S. L., and Der, C. J. (2010) Aberrant Overexpression of the Rgl2 Ral Small GTPase-specific Guanine Nucleotide Exchange Factor Promotes Pancreatic Cancer Growth through Ral-dependent and Ral-independent Mechanisms. J. Biol. Chem. 285, 34729–34740.
Aghajanian, A., Wittchen, E. S., Campbell, S. L., and Burridge, K. (2009) Direct Activation of RhoA by Reactive Oxygen Species Requires a Redox-Sensitive Motif. PLoS One. 4, e8045.
Palmer, S. M., Playford, M. P., Craig, S. W., Schaller, M. D., and Campbell, S. L. (2009) Lipid Binding to the Tail Domain of Vinculin. J. Biol. Chem. 284, 7223–7231.
Dixon, R. D. S., and Campbell, S. L. (2008) 1H, 15N, and 13C NMR chemical shift assignments for the Ig3 domain of palladin. Biomol. NMR Assign. 2, 51–53.
Palmer, S. M., and Campbell, S. L. (2008) Backbone 1H, 13C, and 15N NMR assignments of the tail domain of vinculin. Biomol. NMR Assign. 2, 69–71.
Scheswohl, D. M., Harrell, J. R., Rajfur, Z., Gao, G., Campbell, S. L., and Schaller, M. D. (2008) Multiple paxillin binding sites regulate FAK function. J. Mol. Signal. 3, 1.
Dixon, R. D. S., Arneman, D. K., Rachlin, A. S., Sundaresan, N. R., Costello, M. J., Campbell, S. L., and Otey, C. A. (2008) Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin. VOLUME 283 (2008) PAGES 6222-6231. J. Biol. Chem. 283, 27344.
Palmer, S. M., Schaller, M. D., and Campbell, S. L. (2008) Vinculin Tail Conformation and Self-Association Is Independent of pH and H906 Protonation. Biochemistry. 47, 12467–12475.
Chen, Y., Campbell, S. L., and Dokholyan, N. V. (2007) Deciphering Protein Dynamics from NMR Data Using Explicit Structure Sampling and Selection. Biophys. J. 93, 2300–2306.
RAINES, K., BONINI, M., and CAMPBELL, S. (2007) Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases. Cardiovasc. Res. 75, 229–239.
Wu, Y., Bhattacharyya, D., King, C. L., Baskerville-Abraham, I., Huh, S.-H., Boysen, G., Swenberg, J. A., Temple, B., Campbell, S. L., and Chaney, S. G. (2007) Solution Structures of a DNA Dodecamer Duplex with and without a Cisplatin 1,2-d(GG) Intrastrand Cross-Link: Comparison with the Same DNA Duplex Containing an Oxaliplatin 1,2-d(GG) Intrastrand Cross-Link ,. Biochemistry. 46, 6477–6487.
Heo, J., and Campbell, S. L. (2006) Ras Regulation by Reactive Oxygen and Nitrogen Species. Biochemistry. 45, 2200–2210.
Heo, J., Raines, K. W., Mocanu, V., and Campbell, S. L. (2006) Redox Regulation of RhoA. Biochemistry. 45, 14481–14489.
Ding, F., Prutzman, K. C., Campbell, S. L., and Dokholyan, N. V. (2006) Topological Determinants of Protein Domain Swapping. Structure. 14, 5–14.
Heo, J., Prutzman, K. C., Mocanu, V., and Campbell, S. L. (2005) Mechanism of Free Radical Nitric Oxide-mediated Ras Guanine Nucleotide Dissociation. J. Mol. Biol. 346, 1423–1440.
Heo, J., and Campbell, S. L. (2005) Mechanism of Redox-mediated Guanine Nucleotide Exchange on Redox-active Rho GTPases. J. Biol. Chem. 280, 31003–31010.
Heo, J., and Campbell, S. L. (2005) Nitric oxide and cell signaling: Redox regulation of ras superfamily GTPases. in Nitric Oxide, Cell Signaling, and Gene Expression, pp. 263–289, CRC Press.
Hekman, M., Fischer, A., Wennogle, L. P., Wang, Y. K., Campbell, S. L., and Rapp, U. R. (2005) Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation. FEBS Lett. 579, 464–468.
Heo, J., Thapar, R., and Campbell, S. L. (2005) Recognition and Activation of Rho GTPases by Vav1 and Vav2 Guanine Nucleotide Exchange Factors †. Biochemistry. 44, 6573–6585.
Chaney, S. G., Campbell, S. L., Bassett, E., and Wu, Y. (2005) Recognition and processing of cisplatin- and oxaliplatin-DNA adducts. Crit. Rev. Oncol. Hematol. 53, 3–11.
Heo, J., and Campbell, S. L. (2005) Superoxide Anion Radical Modulates the Activity of Ras and Ras-related GTPases by a Radical-based Mechanism Similar to That of Nitric Oxide. J. Biol. Chem. 280, 12438–12445.
Heo, J., and Campbell, S. L. (2004) Mechanism of p21 Ras S-Nitrosylation and Kinetics of Nitric Oxide-Mediated Guanine Nucleotide Exchange †. Biochemistry. 43, 2314–2322.
Karnoub, A. E., Symons, M., Campbell, S. L., and Der, C. J. (2004) Molecular Basis for Rho GTPase Signaling Specificity. Breast Cancer Res. Treat. 84, 61–71.
Dixon, R. D. S., Chen, Y., Ding, F., Khare, S. D., Prutzman, K. C., Schaller, M. D., Campbell, S. L., and Dokholyan, N. V. (2004) New Insights into FAK Signaling and Localization Based on Detection of a FAT Domain Folding Intermediate. Structure. 12, 2161–2171.
Thapar, R., Williams, J. G., and Campbell, S. L. (2004) NMR Characterization of Full-length Farnesylated and Non-farnesylated H-Ras and its Implications for Raf Activation. J. Mol. Biol. 343, 1391–1408.
Wu, Y., Pradhan, P., Havener, J., Boysen, G., Swenberg, J. A., Campbell, S. L., and Chaney, S. G. (2004) NMR Solution Structure of an Oxaliplatin 1,2-d(GG) Intrastrand Cross-link in a DNA Dodecamer Duplex. J. Mol. Biol. 341, 1251–1269.
Gao, G., Prutzman, K. C., King, M. L., Scheswohl, D. M., DeRose, E. F., London, R. E., Schaller, M. D., and Campbell, S. L. (2004) NMR Solution Structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase in Complex with a Paxillin LD Peptide. J. Biol. Chem. 279, 8441–8451.
Heo, J., Gao, G., and Campbell, S. L. (2004) pH-Dependent Perturbation of Ras−Guanine Nucleotide Interactions and Ras Guanine Nucleotide Exchange †. Biochemistry. 43, 10102–10111.
Chaney, S. G., Campbell, S. L., Temple, B., Bassett, E., Wu, Y., and Faldu, M. (2004) Protein interactions with platinum–DNA adducts: from structure to function. J. Inorg. Biochem. 98, 1551–1559.
Gao, G., Williams, J. G., and Campbell, S. L. (2004) Protein–Protein Interaction Analysis by Nuclear Magnetic Resonance Spectroscopy. in Protein-Protein Interactions, pp. 079–092, Humana Press, New Jersey, 261, 079–092.
Solski, P. A., Wilder, R. S., Rossman, K. L., Sondek, J., Cox, A. D., Campbell, S. L., and Der, C. J. (2004) Requirement For C-terminal Sequences in Regulation of Ect2 Guanine Nucleotide Exchange Specificity and Transformation. J. Biol. Chem. 279, 25226–25233.
Prutzman, K. C., Gao, G., King, M. L., Iyer, V. V., Mueller, G. A., Schaller, M. D., and Campbell, S. L. (2004) The Focal Adhesion Targeting Domain of Focal Adhesion Kinase Contains a Hinge Region that Modulates Tyrosine 926 Phosphorylation. Structure. 12, 881–891.
Thapar, R., Moore, C. D., and Campbell, S. L. (2003) Backbone 1H, 13C, and 15N resonance assignments for the 21 kDa GTPase Rac1 complexed to GDP and Mg2+ [1]. J. Biomol. NMR. 27, 87–88.
Fuentes, E. J., Karnoub, A. E., Booden, M. A., Der, C. J., and Campbell, S. L. (2003) Critical Role of the Pleckstrin Homology Domain in Dbs Signaling and Growth Regulation. J. Biol. Chem. 278, 21188–21196.
Williams, J. G., Pappu, K., and Campbell, S. L. (2003) Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange. Proc. Natl. Acad. Sci. 100, 6376–6381.
Rossman, K. L., Worthylake, D. K., Snyder, J. T., Siderovski, D. P., Campbell, S. L., and Sondek, J. (2002) A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J. 21, 1315–1326.
Booden, M. A., Campbell, S. L., and Der, C. J. (2002) Critical but Distinct Roles for the Pleckstrin Homology and Cysteine-Rich Domains as Positive Modulators of Vav2 Signaling and Transformation. Mol. Cell. Biol. 22, 2487–2497.
Lambert, J. M., Karnoub, A. E., Graves, L. M., Campbell, S. L., and Der, C. J. (2002) Role of MLK3-mediated Activation of p70 S6 Kinase in Rac1 Transformation. J. Biol. Chem. 277, 4770–4777.
Thapar, R., Karnoub, A. E., and Campbell, S. L. (2002) Structural and Biophysical Insights into the Role of the Insert Region in Rac1 Function †. Biochemistry. 41, 3875–3883.
Karnoub, A. E., Worthylake, D. K., Rossman, K. L., Pruitt, W. M., Campbell, S. L., Sondek, J., and Der, C. J. (2001) Molecular basis for Rac1 recognition by guanine nucleotide exchange factors. Nat. Struct. Biol. 8, 1037–1041.
Karnoub, A. E., Der, C. J., and Campbell, S. L. (2001) The Insert Region of Rac1 Is Essential for Membrane Ruffling but Not Cellular Transformation. Mol. Cell. Biol. 21, 2847–2857.
Rossman, K. L., and Campbell, S. L. (2000) Bacterial expressed DH and DH/PH domains. in Methods in Enzymology, pp. 25–38, 325, 25–38.
Williams, J. G., Drugan, J. K., Yi, G.-S., Clark, G. J., Der, C. J., and Campbell, S. L. (2000) Elucidation of Binding Determinants and Functional Consequences of Ras/Raf-Cysteine-rich Domain Interactions. J. Biol. Chem. 275, 22172–22179.
Drugan, J. K., Rogers-Graham, K., Gilmer, T., Campbell, S., and Clark, G. J. (2000) The Ras/p120 GTPase-activating Protein (GAP) Interaction Is Regulated by the p120 GAP Pleckstrin Homology Domain*. J. Biol. Chem. 275, 35021–35027.
Abe, K., Rossman, K. L., Liu, B., Ritola, K. D., Chiang, D., Campbell, S. L., Burridge, K., and Der, C. J. (2000) Vav2 Is an Activator of Cdc42, Rac1, and RhoA. J. Biol. Chem. 275, 10141–10149.
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Bhattacharyya, D., Ramachandran, S., Sharma, S., Pathmasiri, W., King, C. L., Baskerville-Abraham, I., Boysen, G., Swenberg, J. A., Campbell, S. L., Dokholyan, N. V., and Chaney, S. G. (2011) Flanking Bases Influence the Nature of DNA Distortion by Platinum 1,2-Intrastrand (GG) Cross-Links. PLoS One. 6, e23582.
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Palmer, S. M., and Campbell, S. L. (2008) Backbone 1H, 13C, and 15N NMR assignments of the tail domain of vinculin. Biomol. NMR Assign. 2, 69–71.
Scheswohl, D. M., Harrell, J. R., Rajfur, Z., Gao, G., Campbell, S. L., and Schaller, M. D. (2008) Multiple paxillin binding sites regulate FAK function. J. Mol. Signal. 3, 1.
Dixon, R. D. S., Arneman, D. K., Rachlin, A. S., Sundaresan, N. R., Costello, M. J., Campbell, S. L., and Otey, C. A. (2008) Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin. VOLUME 283 (2008) PAGES 6222-6231. J. Biol. Chem. 283, 27344.
Palmer, S. M., Schaller, M. D., and Campbell, S. L. (2008) Vinculin Tail Conformation and Self-Association Is Independent of pH and H906 Protonation. Biochemistry. 47, 12467–12475.
Chen, Y., Campbell, S. L., and Dokholyan, N. V. (2007) Deciphering Protein Dynamics from NMR Data Using Explicit Structure Sampling and Selection. Biophys. J. 93, 2300–2306.
RAINES, K., BONINI, M., and CAMPBELL, S. (2007) Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases. Cardiovasc. Res. 75, 229–239.
Wu, Y., Bhattacharyya, D., King, C. L., Baskerville-Abraham, I., Huh, S.-H., Boysen, G., Swenberg, J. A., Temple, B., Campbell, S. L., and Chaney, S. G. (2007) Solution Structures of a DNA Dodecamer Duplex with and without a Cisplatin 1,2-d(GG) Intrastrand Cross-Link: Comparison with the Same DNA Duplex Containing an Oxaliplatin 1,2-d(GG) Intrastrand Cross-Link ,. Biochemistry. 46, 6477–6487.
Heo, J., and Campbell, S. L. (2006) Ras Regulation by Reactive Oxygen and Nitrogen Species. Biochemistry. 45, 2200–2210.
Heo, J., Raines, K. W., Mocanu, V., and Campbell, S. L. (2006) Redox Regulation of RhoA. Biochemistry. 45, 14481–14489.
Ding, F., Prutzman, K. C., Campbell, S. L., and Dokholyan, N. V. (2006) Topological Determinants of Protein Domain Swapping. Structure. 14, 5–14.
Heo, J., Prutzman, K. C., Mocanu, V., and Campbell, S. L. (2005) Mechanism of Free Radical Nitric Oxide-mediated Ras Guanine Nucleotide Dissociation. J. Mol. Biol. 346, 1423–1440.
Heo, J., and Campbell, S. L. (2005) Mechanism of Redox-mediated Guanine Nucleotide Exchange on Redox-active Rho GTPases. J. Biol. Chem. 280, 31003–31010.
Heo, J., and Campbell, S. L. (2005) Nitric oxide and cell signaling: Redox regulation of ras superfamily GTPases. in Nitric Oxide, Cell Signaling, and Gene Expression, pp. 263–289, CRC Press.
Hekman, M., Fischer, A., Wennogle, L. P., Wang, Y. K., Campbell, S. L., and Rapp, U. R. (2005) Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation. FEBS Lett. 579, 464–468.
Heo, J., Thapar, R., and Campbell, S. L. (2005) Recognition and Activation of Rho GTPases by Vav1 and Vav2 Guanine Nucleotide Exchange Factors †. Biochemistry. 44, 6573–6585.
Chaney, S. G., Campbell, S. L., Bassett, E., and Wu, Y. (2005) Recognition and processing of cisplatin- and oxaliplatin-DNA adducts. Crit. Rev. Oncol. Hematol. 53, 3–11.
Heo, J., and Campbell, S. L. (2005) Superoxide Anion Radical Modulates the Activity of Ras and Ras-related GTPases by a Radical-based Mechanism Similar to That of Nitric Oxide. J. Biol. Chem. 280, 12438–12445.
Heo, J., and Campbell, S. L. (2004) Mechanism of p21 Ras S-Nitrosylation and Kinetics of Nitric Oxide-Mediated Guanine Nucleotide Exchange †. Biochemistry. 43, 2314–2322.
Karnoub, A. E., Symons, M., Campbell, S. L., and Der, C. J. (2004) Molecular Basis for Rho GTPase Signaling Specificity. Breast Cancer Res. Treat. 84, 61–71.
Dixon, R. D. S., Chen, Y., Ding, F., Khare, S. D., Prutzman, K. C., Schaller, M. D., Campbell, S. L., and Dokholyan, N. V. (2004) New Insights into FAK Signaling and Localization Based on Detection of a FAT Domain Folding Intermediate. Structure. 12, 2161–2171.
Thapar, R., Williams, J. G., and Campbell, S. L. (2004) NMR Characterization of Full-length Farnesylated and Non-farnesylated H-Ras and its Implications for Raf Activation. J. Mol. Biol. 343, 1391–1408.
Wu, Y., Pradhan, P., Havener, J., Boysen, G., Swenberg, J. A., Campbell, S. L., and Chaney, S. G. (2004) NMR Solution Structure of an Oxaliplatin 1,2-d(GG) Intrastrand Cross-link in a DNA Dodecamer Duplex. J. Mol. Biol. 341, 1251–1269.
Gao, G., Prutzman, K. C., King, M. L., Scheswohl, D. M., DeRose, E. F., London, R. E., Schaller, M. D., and Campbell, S. L. (2004) NMR Solution Structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase in Complex with a Paxillin LD Peptide. J. Biol. Chem. 279, 8441–8451.
Heo, J., Gao, G., and Campbell, S. L. (2004) pH-Dependent Perturbation of Ras−Guanine Nucleotide Interactions and Ras Guanine Nucleotide Exchange †. Biochemistry. 43, 10102–10111.
Chaney, S. G., Campbell, S. L., Temple, B., Bassett, E., Wu, Y., and Faldu, M. (2004) Protein interactions with platinum–DNA adducts: from structure to function. J. Inorg. Biochem. 98, 1551–1559.
Gao, G., Williams, J. G., and Campbell, S. L. (2004) Protein–Protein Interaction Analysis by Nuclear Magnetic Resonance Spectroscopy. in Protein-Protein Interactions, pp. 079–092, Humana Press, New Jersey, 261, 079–092.
Solski, P. A., Wilder, R. S., Rossman, K. L., Sondek, J., Cox, A. D., Campbell, S. L., and Der, C. J. (2004) Requirement For C-terminal Sequences in Regulation of Ect2 Guanine Nucleotide Exchange Specificity and Transformation. J. Biol. Chem. 279, 25226–25233.
Prutzman, K. C., Gao, G., King, M. L., Iyer, V. V., Mueller, G. A., Schaller, M. D., and Campbell, S. L. (2004) The Focal Adhesion Targeting Domain of Focal Adhesion Kinase Contains a Hinge Region that Modulates Tyrosine 926 Phosphorylation. Structure. 12, 881–891.
Thapar, R., Moore, C. D., and Campbell, S. L. (2003) Backbone 1H, 13C, and 15N resonance assignments for the 21 kDa GTPase Rac1 complexed to GDP and Mg2+ [1]. J. Biomol. NMR. 27, 87–88.
Fuentes, E. J., Karnoub, A. E., Booden, M. A., Der, C. J., and Campbell, S. L. (2003) Critical Role of the Pleckstrin Homology Domain in Dbs Signaling and Growth Regulation. J. Biol. Chem. 278, 21188–21196.
Williams, J. G., Pappu, K., and Campbell, S. L. (2003) Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange. Proc. Natl. Acad. Sci. 100, 6376–6381.
Rossman, K. L., Worthylake, D. K., Snyder, J. T., Siderovski, D. P., Campbell, S. L., and Sondek, J. (2002) A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J. 21, 1315–1326.
Booden, M. A., Campbell, S. L., and Der, C. J. (2002) Critical but Distinct Roles for the Pleckstrin Homology and Cysteine-Rich Domains as Positive Modulators of Vav2 Signaling and Transformation. Mol. Cell. Biol. 22, 2487–2497.
Lambert, J. M., Karnoub, A. E., Graves, L. M., Campbell, S. L., and Der, C. J. (2002) Role of MLK3-mediated Activation of p70 S6 Kinase in Rac1 Transformation. J. Biol. Chem. 277, 4770–4777.
Thapar, R., Karnoub, A. E., and Campbell, S. L. (2002) Structural and Biophysical Insights into the Role of the Insert Region in Rac1 Function †. Biochemistry. 41, 3875–3883.
Karnoub, A. E., Worthylake, D. K., Rossman, K. L., Pruitt, W. M., Campbell, S. L., Sondek, J., and Der, C. J. (2001) Molecular basis for Rac1 recognition by guanine nucleotide exchange factors. Nat. Struct. Biol. 8, 1037–1041.
Karnoub, A. E., Der, C. J., and Campbell, S. L. (2001) The Insert Region of Rac1 Is Essential for Membrane Ruffling but Not Cellular Transformation. Mol. Cell. Biol. 21, 2847–2857.
Rossman, K. L., and Campbell, S. L. (2000) Bacterial expressed DH and DH/PH domains. in Methods in Enzymology, pp. 25–38, 325, 25–38.
Williams, J. G., Drugan, J. K., Yi, G.-S., Clark, G. J., Der, C. J., and Campbell, S. L. (2000) Elucidation of Binding Determinants and Functional Consequences of Ras/Raf-Cysteine-rich Domain Interactions. J. Biol. Chem. 275, 22172–22179.
Drugan, J. K., Rogers-Graham, K., Gilmer, T., Campbell, S., and Clark, G. J. (2000) The Ras/p120 GTPase-activating Protein (GAP) Interaction Is Regulated by the p120 GAP Pleckstrin Homology Domain*. J. Biol. Chem. 275, 35021–35027.
Abe, K., Rossman, K. L., Liu, B., Ritola, K. D., Chiang, D., Campbell, S. L., Burridge, K., and Der, C. J. (2000) Vav2 Is an Activator of Cdc42, Rac1, and RhoA. J. Biol. Chem. 275, 10141–10149.
Whitehead, I. P., Lambert, Q. T., Glaven, J. A., Abe, K., Rossman, K. L., Mahon, G. M., Trzaskos, J. M., Kay, R., Campbell, S. L., and Der, C. J. (1999) Dependence of Dbl and Dbs Transformation on MEK and NF-κB Activation. Mol. Cell. Biol. 19, 7759–7770.
Graham, S. M., Oldham, S. M., Martin, C. B., Drugan, J. K., Zohn, I. E., Campbell, S., and Der, C. J. (1999) TC21 and Ras share indistinguishable transforming and differentiating activities. Oncogene. 18, 2107–2116.
Winkler, D. G., Cutler, R. E., Drugan, J. K., Campbell, S., Morrison, D. K., and Cooper, J. A. (1998) Identification of Residues in the Cysteine-rich Domain of Raf-1 That Control Ras Binding and Raf-1 Activity*. J. Biol. Chem. 273, 21578–21584.
Campbell, S. L., Khosravi-Far, R., Rossman, K. L., Clark, G. J., and Der, C. J. (1998) Increasing complexity of Ras signaling. Oncogene. 17, 1395–1413.
Zohn, I. M., Campbell, S. L., Khosravi-Far, R., Rossman, K. L., and Der, C. J. (1998) Rho family proteins and Ras transformation: the RHOad less traveled gets congested. Oncogene. 17, 1415–1438.
Clark, G. J., Drugan, J. K., Rossman, K. L., Carpenter, J. W., Rogers-Graham, K., Fu, H., Der, C. J., and Campbell, S. L. (1997) 14-3-3 ζ Negatively Regulates Raf-1 Activity by Interactions with the Raf-1 Cysteine-rich Domain. J. Biol. Chem. 272, 20990–20993.
Lander, H. M., Hajjar, D. P., Hempstead, B. L., Mirza, U. A., Chait, B. T., Campbell, S., and Quilliam, L. A. (1997) A Molecular Redox Switch on p21ras: STRUCTURAL BASIS FOR THE NITRIC OXIDE-p21ras INTERACTION*. J. Biol. Chem. 272, 4323–4326.
Whitehead, I. P., Campbell, S., Rossman, K. L., and Der, C. J. (1997) Dbl family proteins. Biochim. Biophys. Acta - Rev. Cancer. 1332, F1–F23.
Khosravi-Far, R., Campbell, S., Rossman, K. L., and Der, C. J. (1997) Increasing Complexity of Ras Signal Transduction: Involvement of Rho Family Proteins (Vande Woude, G. F., and Klein, G. B. T.-A. in C. R. eds), pp. 57–107, Academic Press, 72, 57–107.
Mott, H. R., Carpenter, J. W., and Campbell, S. L. (1997) Structural and Functional Analysis of a Mutant Ras Protein That Is Insensitive to Nitric Oxide Activation †. Biochemistry. 36, 3640–3644.
Quilliam, L. A., Hisaka, M. M., Zhong, S., Lowry, A., Mosteller, R. D., Han, J., Drugan, J. K., Broek, D., Campbell, S. L., and Der, C. J. (1996) Involvement of the Switch 2 Domain of Ras in Its Interaction with Guanine Nucleotide Exchange Factors. J. Biol. Chem. 271, 11076–11082.
Clark, G. J., Drugan, J. K., Terrell, R. S., Bradham, C., Der, C. J., Bell, R. M., and Campbell, S. (1996) Peptides containing a consensus Ras binding sequence from Raf-1 and theGTPase activating protein NF1 inhibit Ras function. Proc. Natl. Acad. Sci. 93, 1577 LP – 1581.
Drugan, J. K., Khosravi-Far, R., White, M. A., Der, C. J., Sung, Y.-J., Hwang, Y.-W., and Campbell, S. L. (1996) Ras Interaction with Two Distinct Binding Domains in Raf-1 5 Be Required for Ras Transformation. J. Biol. Chem. 271, 233–237.
Lander, H. M., Milbank, A. J., Tauras, J. M., Hajjar, D. P., Hempstead, B. L., Schwartz, G. D., Kraemer, R. T., Mirza, U. A., Chait, B. T., Burk, S. C., and Quilliam, L. A. (1996) Redox regulation of cell signalling. Nature. 381, 380–381.
Mott, H. R., Carpenter, J. W., Zhong, S., Ghosh, S., Bell, R. M., and Campbell, S. L. (1996) The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site. Proc. Natl. Acad. Sci. 93, 8312–8317.
Quilliam, L. A., Zhong, S., Rabun, K. M., Carpenter, J. W., South, T. L., Der, C. J., and Campbell-Burk, S. (1995) Biological and structural characterization of a Ras transforming mutation at the phenylalanine-156 residue, which is conserved in all members of the Ras superfamily. Proc. Natl. Acad. Sci. 92, 1272 LP – 1276.
Campbell-Burk, S. L., and Carpenter, J. W. B. T.-M. in E. (1995) [1] Refolding and purification of ras proteins. in Small GTPases and Their Regulators, Part A: RAS Family, pp. 3–13, Academic Press, 255, 3–13.
Brtva, T. R., Drugan, J. K., Ghosh, S., Terrell, R. S., Campbell-Burk, S., Bell, R. M., and Der, C. J. (1995) Two Distinct Raf Domains Mediate Interaction with Ras (∗). J. Biol. Chem. 270, 9809–9812.
Campbell-Burk, S., and Zhong, S. (1994) Biomolecular applications of heteronuclear multidimensional NMR. Curr. Opin. Biotechnol. 5, 346–354.
Quilliam, L. A., Kato, K., Rabun, K. M., Hisaka, M. M., Huff, S. Y., Campbell-Burk, S., and Der, C. J. (1994) Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors. Mol. Cell. Biol. 14, 1113–1121.
Deloskey, R. J., Vandyk, D. E., Vanaken, T. E., and Campbellburk, S. (1994) Isolation and Refolding of H-ras from Inclusion Bodies of Escherichia coli: Refold Procedure and Comparison of Refolded and Soluble H-ras. Arch. Biochem. Biophys. 311, 72–78.
YAMAZAKI, T., NICHOLSON, L. K., TORCHIA, D. A., STAHL, S. J., KAUFMAN, J. D., WINGFIELD, P. T., DOMAILLE, P. J., and CAMPBELL-BURK, S. (1994) Secondary structure and signal assignments of human-immunodeficiency-virus-1 protease complexed to a novel, structure-based inhibitor. Eur. J. Biochem. 219, 707–712.
Kraulis, P. J., Domaille, P. J., Campbell-Burk, S. L., Van Aken, T., and Laue, E. D. (1994) Solution Structure and Dynamics of Ras p21.cntdot.GDP Determined by Heteronuclear Three- and Four-Dimensional NMR Spectroscopy. Biochemistry. 33, 3515–3531.
Mueller, L., Campbell-Burk, S., and Domaille, P. (1992) 15N-correlated three-dimensional relayed NOESY experiments in uniformly 15N-labeled proteins. J. Magn. Reson. 96, 408–415.
Boucher, W., Laue, E. D., Campbell-Burk, S. L., and Domaille, P. J. (1992) Improved 4D NMR experiments for the assignment of backbone nuclei in13C/15N labelled proteins. J. Biomol. NMR. 2, 631–637.
Campbell-Burka, S. L., Domaillea, P. J., Starovasnik, M. A., Boucher, W., and Laue, E. D. (1992) Sequential assignment of the backbone nuclei (1H,15N and13C) of c-H-ras p21 (1–166).GDP using a novel 4D NMR strategy. J. Biomol. NMR. 2, 639–646.
Campbell-Burk, S., Domaille, P., and Mueller, L. (1991) Observation of labile amide protons via indirect detection of 15N single-quantum transitions. J. Magn. Reson. 93, 171–177.
Campbell-Burk, S. (1989) Structural and dynamic differences between normal and transforming N-ras gene products: a phosphorus-31 and isotope-edited proton NMR study. Biochemistry. 28, 9478–9484.
Campbell-Burk, S. L., Den Hollander, J. A., Alger, J. R., and Shulman, R. G. (1987) Phosphorus-31 NMR saturation-transfer and carbon-13 NMR kinetic studies of glycolytic regulation during anaerobic and aerobic glycolysis. Biochemistry. 26, 7493–7500.
Campbell-Burk, S. L., Jones, K. A., and Shulman, R. G. (1987) Phosphorus-31 NMR saturation-transfer measurements in Saccharomyces cerevisiae: characterization of phosphate exchange reactions by iodoacetate and antimycin A inhibition. Biochemistry. 26, 7483–7492.
Campbell-Burk, S. L., and Shulman, R. G. (1987) High-Resolution NMR Studies of Saccharomyces Cerevisiae. Annu. Rev. Microbiol. 41, 595–616.
Csatorday, K., Campbell, S., and Zilinskas, B. A. (1986) Exciton interactions in phycoerythrin. Photosynth. Res. 10, 209–215.
Campbell, S. L., Jones, K. A., and Shulman, R. G. (1985) In vivo 31P nuclear magnetic resonance saturation transfer measurements of phosphate exchange reactions in the yeast Saccharomyces cerevisiae. FEBS Lett. 10.1016/0014-5793(85)80148-4.
Degani, H., Laughlin, M., Campbell, S., and Shulman, R. G. (1985) Kinetics of creatine kinase in heart: a phosphorus-31 NMR saturation- and inversion-transfer study. Biochemistry. 24, 5510–5516.